Cochrane Clinical Answers (CCAs) provide a readable, digestible, clinically focused entry point to rigorous research from Cochrane Reviews. They are designed to be actionable and to inform point of care decision making.
Below are recent cancer related Cochrane clinical questions, click on the links to view answers.
How do interventions for the management of malignant pleural effusions compare? 28 September 2020.
What are the effects of fibrates used for prevention of melanoma? 10 September 2020.
What is the accuracy of reflectance confocal microscopy (RCM) for the diagnosis of basal cell carcinoma (BCC) of the skin in adults? 10 September 2020.
What are the effects of statins used for prevention of melanoma? 10 September 2020.
What is the accuracy of tests used for primary screening for cervical intraepithelial neoplasia grade 2+ (CIN2+)? 8 August 2020.
Moloney BM, McAnena PF, Ryan ÉJ, Beirn EO, Waldron RM, Connell AO, Walsh S, Ennis R, Glynn C, Lowery AJ, McCarthy PA, Kerin MJ. The Impact of Preoperative Breast Magnetic Resonance Imaging on Surgical Management in Symptomatic Patients With Invasive Lobular Carcinoma. Breast Cancer (Auckl). 2020 Aug 14;14:1178223420948477. doi: 10.1177/1178223420948477. PMID: 32863709; PMCID: PMC7430084.
Kalachand RD, O'Riain C, Toomey S, Carr A, Timms KM, O'Toole S, Madden S, Bates M, O'Leary JJ, Gleeson N, O'Donnell D, Grogan L, Breathnach O, Farrelly A, Stordal B, Hennessy BT. Prevalence of tumor BRCA1 and BRCA2 dysfunction in unselected patients with ovarian cancer. Obstet Gynecol Sci. 2020 Sep;63(5):643-654. doi: 10.5468/ogs.20033. Epub 2020 Sep 2. PMID: 32872764.
Grant-Freemantle MC, Lane O'Neill B, Clover AJP. The effectiveness of radiotherapy in the treatment of head and neck mucosal melanoma: Systematic review and meta-analysis. Head Neck. 2020 Sep 14. doi: 10.1002/hed.26470. Epub ahead of print. PMID: 32926490.
Challapalli RS, Dwyer RM, McInerney N, Kerin MJ, Lowery AJ. Effect of Breast Cancer and Adjuvant Therapy on Adipose-Derived Stromal Cells: Implications for the Role of ADSCs in Regenerative Strategies for Breast Reconstruction. Stem Cell Rev Rep. 2020 Sep 14. doi: 10.1007/s12015-020-10038-1. Epub ahead of print. PMID: 32929604.
Conroy MJ, Kennedy SA, Doyle SL, Hayes B, Kavanagh M, P van der Stok E, O'Sullivan K, Cathcart MC, Reynolds JV, Lysaght J. A Study of the Immune Infiltrate and Patient Outcomes in Esophageal Cancer. Carcinogenesis. 2020 Sep 17:bgaa101. doi: 10.1093/carcin/bgaa101. Epub ahead of print. PMID: 32940666.
Kalachand RD, O'Riain C, Toomey S, et al. Prevalence of tumor BRCA1 and BRCA2 dysfunction in unselected patients with ovarian cancer [published online ahead of print, 2020 Sep 2]. Obstet Gynecol Sci. 2020;10.5468/ogs.20030. doi:10.5468/ogs.20030
Cummins D, O'Sullivan S, Dunne M, et al. Determining normal tissue dose in intracranial stereotactic radiosurgery: A diameter-based predictive nomogram. J Radiosurg SBRT. 2020;7(1):67-75.
Irish Cancer Society is now accepting applications for the grant call:
Misinformation and Disinformation in Cancer: An Intervention Development Award
The purpose of this award is to develop a theory-driven and evidence-based intervention aimed at making those affected by a cancer diagnosis more resilient to the misinformation/disinformation they will likely experience over the course of their treatment and beyond. Funding of €65,000 is available for project of up to a maximum of 18 months duration.
Deadline for applications: 10 November 2020 @ 3pm.
For more information, please see Irish Cancer Society website. Applications can be made through our Online Grant System.
Simcock R, Thomas TV, Estes C, et al. COVID-19: Global radiation oncology's targeted response for pandemic preparedness. Clin Transl Radiat Oncol. 2020;22:55-68. Published 2020 Mar 24. doi:10.1016/j.ctro.2020.03.009
Filippi AR, Russi E, Magrini SM, Corvò R. Letter from Italy: First practical indications for radiation therapy departments during COVID-19 outbreak. Int J Radiat Oncol Biol Phys. 2020;107(3):597-599. doi:10.1016/j.ijrobp.2020.03.007
Thomson DJ, Palma D, Guckenberger M, et al. Practice Recommendations for Risk-Adapted Head and Neck Cancer Radiation Therapy During the COVID-19 Pandemic: An ASTRO-ESTRO Consensus Statement. Int J Radiat Oncol Biol Phys. 2020;107(4):618-627. doi:10.1016/j.ijrobp.2020.04.016
Guckenberger M, Belka C, Bezjak A, et al. Practice recommendations for lung cancer radiotherapy during the COVID-19 pandemic: An ESTRO-ASTRO consensus statement. Radiother Oncol. 2020;146:223-229. doi:10.1016/j.radonc.2020.04.001
Porceddu SV, Daniels C, Yom SS, et al. Head and Neck Cancer International Group (HNCIG) Consensus Guidelines for the Delivery of Postoperative Radiation Therapy in Complex Cutaneous Squamous Cell Carcinoma of the Head and Neck (cSCCHN). Int J Radiat Oncol Biol Phys. 2020;107(4):641-651. doi:10.1016/j.ijrobp.2020.03.024
Marie Carrigan
Hospital Librarian
National Health Library and Knowledge Service
St. Luke's Radiation Oncology Network
Dymphna McGettigan
Hospital Librarian
National Health Library and Knowledge Service
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